Blocking the uptake of large amounts of cholesterol into brain cancer cells could provide a new strategy to battle glioblastoma, one of the most deadly brain malignancies, researchers at UCLA's Jonsson Comprehensive Cancer Center have found.
The study, done using cells lines, mouse models and an analysis of tissue from brain cancer patients, uncovered a novel mechanism by which the most commonly activated oncogene, the mutated epidermal growth factor receptor (EGFR), overcomes normal cell regulatory mechanisms to feed large amounts of cholesterol to the brain cancer cells, said senior study author Dr. Paul Mischel, a Jonsson Cancer Center researcher and a professor of pathology and laboratory medicine and of molecular and medical pharmacology.
The study appears Sept. 15 in Cancer Discovery, the newest peer-reviewed journal of the American Association for Cancer Research. It shows that EGFRvIII, common in glioblastoma, promotes the import of cholesterol into cancer cells by up-regulating its cellular receptor, the LDL receptor, promoting rapid tumor growth and survival.
read more : http://insciences.org/article.php?article_id=10338&utm_source=feedburner...
Source: http://www.zangani.com/node/196265
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